Another research group studied by immunoprecipitation the correlation between anti-Ku antibodies in SLE sera and antibodies against four different DNA repair proteins (DNA-PK, PARP, Mre11, and Werner protein) and found that more than 50% of anti-Ku positive sera contained at least one out of four autoantibodies, providing further evidence that abnormal DSB repair influences the development of certain autoimmune diseases [125]. Here, PRKDC is linked to systemic lupus erythematosus.