TREX1 and myocarditis: Of note, type I IFN is indeed implicated in the inflammatory myocarditis and early mortality observed in this mouse model, as disease manifestations were strikingly attenuated in Trex1-deficient mice also lacking the type I IFN receptor (IFNαR1) [76], and were also improved in mice treated with an inhibitor of the downstream kinase TANK-binding kinase 1 [77].