Moreover, in accordance with previous data showing that the histone deacetylase inhibitor (HDACi) vorinostat reverses the abnormal chromatin compaction that impedes the access of DNA repair proteins to sites of DNA damage, we found that treatment of PBMCs from quiescent SLE patients with this drug resulted in increased efficiency of the DNA repair machinery and decreased DNA damage burden of these cells [4]. Here, XRCC6P5 is linked to systemic lupus erythematosus.