Of note, this axis, that being oxidized DNA-cGAS-STING-type I IFN, was verified in a SLE mouse model [Murphy Roths Large lymphoproliferation (MRL/lpr) mice], as well as in skin biopsies of patients with SLE, where oxidized DNA co-localized with the type I IFN-induced gene myxovirus (influenza) resistance 1 (MX1) [90]. Here, CGAS is linked to systemic lupus erythematosus.