PRKDC and systemic lupus erythematosus: Accordingly, several apoptosis-associated genes [Protein phosphatase 1 regulatory subunit 15A (PPP1R15A), cyclin-dependent kinase inhibitor 1A (CDKN1A), BRCA1-associated RING domain protein 1 (BARD1), RAD21, RAD9 checkpoint clamp component A (RAD9A), Protein Kinase, DNA-Activated, Catalytic Subunit (PRKDC), Calcium and integrin-binding protein 1 (CIB1), BRCA1, Abelson murine leukemia viral oncogene homolog 1 (ABL1), checkpoint kinase 2 (CHEK2), and Bcl-2-binding component 3 (BBC3)] were found to be significantly overexpressed in SLE compared with healthy controls [4].