Moreover, Exo facilitate the EMT of melanoma cells consisting of the acquisition of the mesenchymal phenotype and pro-invasive behavior by up-regulating Let7a, Let7i, and miR-191, which, in turn, down-regulate E-cadherin and activate the expression of vimentin, ZEB2, and SNAIL2 [28]. The gene discussed is CDH1; the disease is melanoma.