In this regard, the cargo of miRNAs via melanoma-derived Exo has a pivotal role in tumor progression as described for miR-9, whose exosomal transfer into endothelial cells can activate their migratory and pro-angiogenic potential by prompting the signal transducer and activator of transcription 3 (STAT3) pathway [4,96]. The gene discussed is STAT3; the disease is melanoma.