Tumor cells undergoing EMT generally produce an increased amount of ECM proteins, such as collagens, Fibronectin (FN), and vitronectin, and often cooperate with the cells of the local niche (such as cancer-associated fibroblasts, (CAFs), and tumor-associated macrophages, (TAM)) to remodel surrounding tissues to facilitate angiogenesis and cellular invasion, and to modulate local immunity. This evidence concerns the gene VTN and neoplasm.