In the same study, oral administration of DIM in combination with intraperitoneal administration of cisplatin treatment reduced tumor volume by 65% due to downregulation of pY-STAT3, STAT3, and Mcl-1 levels with simultaneously increased cleavage of Caspase 3 and poly ADP-ribose polymerase (PARP) activity. This evidence concerns the gene STAT3 and neoplasm.