During Frame II, the untreated arm had a much higher incidence rate of HCC recurrence than the DAA and Peg-IFN/RBV arms, while the Peg-IFN/RBV arm had the lowest incidence rate of HCC recurrence (Peg-IFN/RBV vs. DAA vs. untreated: 1152.5 vs. 3126.2 vs. 6652.7/104 person-years, overall log-rank p < 0.001), as seen in Table 1 and Supplementary Figure S1B. Here, IFNA1 is linked to hepatocellular carcinoma.