IFNA1 and hepatocellular carcinoma: Moreover, several reports with single-arm DAA-treated HCV-HCC patients declared abruptly increased HCC recurrence rate after antiviral treatment [11,12,13,14], while conflicting results have been reported in other studies comparing to the untreated [15,16,17,18,19,20,21,22,23,24,25] or IFN-treated groups [10,21,26,27,28,29,30].