Overall, the results support that a low expression level of IF1 in colon cancer cells favors metastatic disease because the operation of at least two contributing factors: (i) the higher resistance of cancer cells to undergo anoikis upon cell detachment and, (ii) the lower tumor infiltration and cytotoxicity of NK cells observed in these carcinomas. This evidence concerns the gene ATP5IF1 and malignant colon neoplasm.