On the other hand, p21-activated kinase (PAK), Ephrin receptor, p38 MAPK, ERK/MAPK, HGF, PDGF and renal cell carcinoma signaling, that are known to increase the aggressiveness of cancer, are predicted pathways activated in shIF1 cells at the transcriptomic level, although no evidence for such activations were obtained at the protein level. This evidence concerns the gene HGF and hereditary clear cell renal cell carcinoma.