PTGS2 and colonic neoplasm: Consistently, target genes of NFAT were regulated upon changes in PEP concentrations; cyclooxygenase 2 (PTGS2), an immune-modulator and a negative prognostic factor in colon cancer [26] by promoting tumor progression and metastasis [27]; and IL-6, a cytokine implicated in cancer progression [28], and tumorigenicity [29].