The study of DNA methylation pattern of the 7 CpGs in the INS gene promoter revealed that T1DM patients have a lower methylation at CpGs −19, −135, and −234 (p = 2.10−16) and a higher methylation at CpG −180 than controls, while methylation was comparable at CpGs −69, −102, −206. Here, INS is linked to type 1 diabetes mellitus.