They identified 88 CpG sites (of them 55 were hypermethylated and 33 were hypomethylated) displaying significant methylation changes in all T1DM-discordant MZ twin pairs, including hypermethylation of HLA-DOB and HLA-DQA2 genes in patients [26]. Here, HLA-DQA2 is linked to type 1 diabetes mellitus.