Many analyses have proved that DQB1*0302 allele is the strongest susceptibility genetic factor and that the heterozygous combination of HLA-DR4-DQA1*0301-DQB1*0302 and HLA-DR3-DQA1*0501-DQB1*0201 haplotypes results in a synergistically increased predisposition to T1DM [4]. Here, HLA-DQA1 is linked to type 1 diabetes mellitus.