HLA-DQB1 and type 1 diabetes mellitus: The loci of variant chromatin modifications were also located close to DQB1 and DRB1 genes: Monocytes from T1DM patients had lower levels of H3K9Ac 4 kb upstream of HLA-DRB1 and higher levels of H3K9Ac 4 kb upstream of HLA-DQB1 [47].