In K562, annexin A1 could have a role as tumor suppressor: Zhu et al. observed annexin A1 downregulation in adriamycin-resistant K562 cells compared with nonresistant cells, and demonstrated that annexin A1 knockdown and overexpression decreased and increased, respectively, adriamycin sensitivity of K562 cells [71]. The gene discussed is ANXA1; the disease is neoplasm.