TP53 and hepatocellular carcinoma: On the other hand, besides playing a role in stress granule formation [47], G3BP1 has been also reported as a protein involved in the control of cell proliferation, promoting S-phase entry in fibroblasts [48], in the regulation of apoptosis through interaction with p53 and its translocation [49], and, more recently, in the oncogenic pathways in several human cancers, including breast, gastric, colon, and liver carcinomas [50,51,52,53].