HSPB1 and myelofibrosis: In the specific context of thrombopoietin- and JAK2V617F-induced myelofibrosis (a chronic degenerative disorder of the hematopoietic system associated with the aberrant activation of the JAK/STAT pathway) [142], our team has recently shown that HSP27 interacts directly with JAK2/STAT5, stabilizing the complex.