ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: In cancer cells derived from chronic myeloid leukemia cells, BCR-ABL tyrosine kinase activity results in the phosphorylation and activation of AKT, and in the phosphorylation and DNA-binding activity of STAT5, which leads in turn to an increase in the expression of antiapoptotic protein Bcl-xL [171].