Classical Hodgkin lymphoma (HL), a common cancer in young adults, is characterized by the presence of Reed-Sternberg cells, which harbor various recurrent genetic lesions, including chromosome 9p24 amplification (e.g., copy number gain of JAK2, PD-L1, and PD-L2) and mutations in genes in the JAK–STAT and NF-κB signaling pathways (e.g., STAT6, SOCS1, TNFAIP3, and NFKBIE) [92,93,94,95,96,97]. The gene discussed is CD274; the disease is cancer.