A successful study using an interesting animal model was carried out by Lee et al., who found evidence that in transgenic mice, fed a HFD, hepatic triglyceride levels do not arise from augmented hepatic de novo lipogenesis, decreased hepatic free fatty acid oxidation, or decreased very-low-density lipoprotein secretion, establishing that retinol binding protein 4 (RBP4) is expressed in adipocytes and induces hepatic steatosis as a consequence of the principal effects occurring in adipose tissue [71]. Here, RBP4 is linked to Hepatic steatosis.