IL6 and metabolic dysfunction-associated steatohepatitis: With regards to IL-6, most interestingly, recent results showed that different sex hormone-related interventions affected the severity of NASH, likely by impacting on the level of sex hormones and modulating the Toll-Like Receptor-MyD88-IL-6 signalling pathway, clearly reinforcing the hypothesis that IL-6 plays a key role in worsening the simpler fatty liver disease [30].