Patatin-like phospholipase domain-containing protein 3 (PNPLA3) (PNPLA3 p.I148M polymorphism), expressed in the liver and easily discovered in subcutaneous adipose tissue of obese patients, also called adiponutrin, has been involved in the pathogenesis of NAFLD [12,13,14], as well as in the alcoholic form [15,16]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.