Other components of the SWI/SNF complex, such as ARID1A, are highly mutated in several cancer types, but rarely altered in ccRCC (e.g., ARID1A is mutated in 49% of ovarian clear cell carcinomas, 39% of endometrial cancers, and only in 3% of ccRCC tumors). The gene discussed is ARID1A; the disease is nonpapillary renal cell carcinoma.