In the clinical setting, it has concordantly been shown that circulating and/or PBMC levels of IL37 are increased in several autoimmune diseases including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), inflammatory bowel disease, ankylosing spondylitis, psoriasis, and Graves’ disease [25]. This evidence concerns the gene IL37 and ankylosing spondylitis.