The qRT-PCR analysis showed a significant decrease of hnRNPA2/B1 mRNA expression in cocultured and activated PBMCs of patients compared to the activated PBMCs alone (2.31 ± 0.86 vs. 1.24 ± 0.20, 1.28 ± 0.27 vs. 0.47 ± 0.37 and 1.36 ± 0.30 vs. 0.18 ± 0.74 in thyroiditis, Addison’s disease and APS respectively) (Figure 2A). This evidence concerns the gene HNRNPA2B1 and primary adrenal insufficiency.