TARDBP and amyotrophic lateral sclerosis: Cassiano and colleagues, using chemical proteomics, noted that the terpenoid heteronemin (206), isolated from the marine sponge Hyrtios sp., targeted TDP-43, a major component of inclusions that characterize amyotrophic lateral sclerosis and front-temporal lobar degeneration, by lowering its affinity “towards nucleic acids”, and thus becoming a “relevant chemical tool in the study of TDP-43 related processes” [222].