IL6 and Sepsis: Yang and colleagues reported that the polyketide 8,8′-bieckol (146), isolated from the edible marine brown alga Ecklonia cava, significantly inhibited both pro-inflammatory NO, prostaglandin E2 (PGE2), and interleukin 6 (IL-6) production, as well as gene expression by downregulating NF-κB signaling pathway and ROS accumulation in both LPS-stimulated primary macrophages and RAW 264.7 macrophages, thus demonstrating the compound’s “anti-inflammatory potential...in systemic inflammatory conditions such as sepsis” [166].