PPARGC1A and Familial prostate cancer: It was shown that in prostate cancer, among 10 co-regulators of a metabolic switch, the peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC1α)—regulating the activity of estrogen-related receptor alpha (ERRα)—was identified, as well as that downregulation of PGC1α promoted metastasis and disease progression [97].