To support this, several recessive genetic loss-of-function variants in the MC1R gene increase the risk of developing cutaneous melanoma [43] and have been found to be associated to phenotypic features related to sun sensitivity in European populations [44].The high signal in region 2, located on OAR 6, harbored the KIT and platelet derived growth factor receptor alpha PDGFRA genes, which are implicated and interact in the functional pathway of coat color in different mammals. Here, MC1R is linked to cutaneous melanoma.