A central role of glands in implantation is also suggested by loss-of-function studies of genes involved in epithelial morphogenesis and proliferation in mice, for example, ablation of the cell–cell adhesion molecule Cdh1 results in epithelial disorganization and absence of glands in the neonatal uterus, with consequent infertility [46]; moreover, conditional knock-out of Sox17 in the uterus is associated with impaired endometrial adenogenesis and infertility [47]. The gene discussed is CDH1; the disease is Infertility.