Importantly, the intracranial injection of an SRSF1-targeted DRO in a GBM mouse model decreased the oncogenic properties of cancer cells by reverting the splicing of oncogenic splice variants of SRSF1-target genes (INSR, U2AF1, MKNK2, USP8; see Table 2) [128]. This evidence concerns the gene SRSF1 and glioblastoma.