ERBB2 and breast cancer: This promising data led to the engineering of Angiopep2 conjugates with targeted therapies: a combination of an anti-epidermal growth factor reception (EGFR) and Angiopep2, with promising results in murine models of glioblastoma [114], and a combination of Angiopep2 with a new anti-HER2 antibody, with a strong brain uptake in xenograft models of human epidermal receptor (HER)-overexpressing breast cancer brain metastasis [115].