RPS3 and infection: HSV-1 infection activates a host type I IFN response in the early infection, but the functionality of this response is subsequently blocked by viral proteins [49,50], including ICP0 [51], US11 [52], UL36 [53], UL42 [54], VP16 [55], VP24 [56], US3 [57] and UL46 [58].