GATA6 and colorectal carcinoma: For example, the serum miR-203 level of stage III–IV patients is higher than that of stage I–II patients [86] In the CRC cell lines HCT-116 and HT-29, miR-203 acts as a tumor suppressor to suppress tumorsphere formation, self-renewal ability, CSC migration, and the expression of stem markers via direct inhibition of GATA-binding protein 6 (GATA6).