IGF2BP2 and hepatocellular carcinoma: Interestingly, p62/IMP2 was highly overexpressed in well-differentiated cell lines (HepG2, Hep3B, and Huh7), whereas they were slightly overexpressed in poorly differentiated cell lines (SNU449) (Figure 1C) [21], which supported our IHC results that p62/IMP2 overexpression may occur in the early stage of HCC.