SREBF1 and esophageal squamous cell carcinoma: To determine whether SREBP1 is dysregulated in esophageal cancer, we first performed bioinformatics analysis using Oncomine to investigate the expression of SREBP1, and found that SREBP1 mRNA expression levels in ESCC tumors were higher than those in normal esophageal tissues in two independent datasets (Figure 1A) [28,29].