In addition, these authors showed that the proliferation of OE33 and OE19 cell lines was does-dependently inhibited, while apoptosis was induced by an ERα-specific antagonist (MPP) and an ERβ-specific antagonist (PHTPP), establishing ESR1 and ESR2 as potential therapeutic targets for esophageal adenocarcinoma. This evidence concerns the gene ESR1 and esophageal adenocarcinoma.