SREBF1 and esophageal squamous cell carcinoma: Subsequently, we identified that SREBP1 is a target of tumor suppressor miR-142-5p (as one of the top-ranking miRs); miR-142-5p level was negatively associated with SREBP1 expression in ESCC patient cohort (N = 162, TCGA ESCA database) (Figure 1D).