NFKB1 and neoplasm: It has also been reported that increased expression of MyD88 is related to a decreased sensitivity to chemotherapy (e.g., PTX) in the MyD88-negative OC A2780 cell line [30]; moreover, the activation of MyD88 and NF-kB in MyD88-positive SKOV-3 cells promoted cell proliferation and tumor growth, likely due to the increased secretion of pro-inflammatory cytokines, thus rendering the cells PTX resistant [13].