TRIM63 and neoplasm: As expected, cachectic gastrocnemius muscles showed an upregulation of the E3 ligase genes in both Pan02 (Trim63: p = 0.0017; Fbxo32: p = 0.0015; Fbxo31: p < 0.0001; Fbxo30: p = 0.0410) and FC1242 (Trim63: p = 0.0007; Fbxo32: p = 0.0226; Fbxo31: p = 0.0261; Fbxo30: p = 0.0214) tumor-bearing mice compared to their age-matched controls (Figure 1H).