SMAD4 and pancreatic neoplasm: The Pan02 cell line is a metastatic, SMAD4-null murine PDAC cell line isolated from a primary pancreatic tumor that arose in a C57BL/6 mouse treated with the carcinogen 3-methylcholanthrene [9,22]; and the FC1242 cell line was isolated from a PDAC tumor that arose in a C57BL/6 mouse harboring common genetic drivers of PDAC (LSL-KrasG12D; LSL-Trp53R172H; Pdx1-Cre) [9].