In line with our previous studies on metastatic colon, breast, and lung cancer cachexia [21], we show in the current study that expression of the zinc transporter, Zip14, correlates with increased zinc levels in cachectic muscles in two mouse models of PDAC-associated cachexia, and that ZIP14 is upregulated in the pectoralis and diaphragm muscles from cachectic human PDAC patients. The gene discussed is SLC39A14; the disease is lung cancer.