As noted in the abstract, the conversion of l-glutamine to α-ketoglutarate in cancer cells is almost invariably ascribed to the glutaminase I pathway: l-glutamine is hydrolyzed to l-glutamate followed by conversion of l-glutamate to α-ketoglutarate by an aminotransferase (transaminase) or by glutamate dehydrogenase. The gene discussed is GLS2; the disease is cancer.