Alibolandi et al. adapted the same approach to synthesize PLGA-b-PEG nanoparticles loaded with doxorubicin (Figure 26), followed by anti-EpCAM aptamer functionalization by similar coupling chemistry, showing a higher tumor inhibition in a mouse xenograft model of human small lung cancer compared to non-aptamer-conjugated polymeric nanoparticles [182]. This evidence concerns the gene EPCAM and neoplasm.