For example, carboxy-terminated poly(d,l-lactic-co-glycolic acid)-block-poly(ethylene glycol) (PLGA–b–PEG–COOH) polymer nanoparticles were conjugated to the A10 RNA aptamer (Apt) that binds to prostate-specific membrane antigen (PSMA), and this formulation was evaluated in a LNCaP (PSMA+) xenograft mouse model of prostate cancer [176]. Here, FOLH1 is linked to prostate carcinoma.