THPO and acute myeloid leukemia: In line with these observations, a genome-wide analysis of AML-MSCs confirmed reduced expression of hematopoietic supportive genes, including KIT ligand (KITLG), thrombopoietin (THPO), and angiopoietin (ANGPT1), associated with a reduced proliferation capacity and a perivascular signature of leukemic MSCs [99].