To determine if activation of PlexinB1 affects translocation of GR to the nucleus we monitored the subcellular localization of GR following treatment with two ligands of PlexinB1, Sema4D and Sema3C, using the AR negative prostate cancer cell lines, PC3 and DU145, as models of androgen-independent prostate cancer. Here, NR3C1 is linked to Familial prostate cancer.