The effect of PlexinB1 depletion on GR protein levels in the prostate cancer cell lines was cell-context specific, as previously reported [6]: Knockdown of PlexinB1 expression in DU145 cells resulted in an increase in the levels of GR protein with both siRNAs used, while knockdown with one siRNA in PC3 cells resulted in a decrease in GR levels (Figure 4d). This evidence concerns the gene NR3C1 and Familial prostate cancer.