Of note, DM treatment by RPG might trigger beneficial side effects through FOXO3 inhibition, as a number of studies suggest that inactivation of FOXO proteins may foster cytoprotection in endothelial cells during DM [45,46], prevent insulin resistance through the inhibition of hepatic gluconeogenesis [47], and prevent retinal disease in murine models [48]. Here, FOXO3 is linked to Abnormal retinal morphology.