In summary, we report that RD/ASCs are characterized by a low basal level of CD90 and ICAM-1 expression, elevated spontaneous secretion of IL-1Ra, TSG-6 and sHLA-G, but impaired release of kynurenines and galectin-3, and there are only small differences between ASCs obtained from SLE, SSc, and AS patients. Here, ICAM1 is linked to systemic sclerosis.