Furthermore, statistical analyses of OSCC cohort data (consisting of the oral tongue, buccal mucosa, alveolar, oropharynx, tonsils, floor of the mouth, and base of the tongue) downloaded from the UCSC Xena functional genomics browser (https://xena.ucsc.edu/) was used to further characterize CD47 expression in patients with OSCC; our results indicated that CD47 was overexpressed in the keratinizing, non-keratinizing, and ‘not otherwise specified’ (NOS) squamous cell carcinoma of the oral cavity, which constituted over 75% of HNSCC (Figure 1B). This evidence concerns the gene CD47 and squamous cell carcinoma.