Against the background that c-Myc is a master regulator of cancer transcriptome, epigenome, and immune privilege [16,17], and that OSCC SCs are characterized by ectopic expression of CD133 and pluripotency master regulators, including SOX2, OCT4, and NANOG [18,19], we probed for probable correlation and/or functional association between CD47, OCT4, SOX2, CD133, and c-MYC. This evidence concerns the gene SOX2 and cancer.