CD47 and neoplasm: Interestingly, while we observed no apparent CD47 expression in ‘normal’ non-dysplastic tissues, we observed a graduated mild positive CD47 expression in the ‘non-tumor’ mild to severely dysplastic tissues, moderate expression of CD47 in the early stage (I, II) carcinoma (p < 0.05 vs. normal or mild dysplasia), and strong CD47 staining in the late stage (III and IV) group (p < 0.001 vs. normal or mild dysplasia), especially in the cytomembranous region (Figure 2A–C).