To understand the role of CD47 in OSCC, we performed computational analyses of CD47 RNAseq expression profile in 33 different cancer types (n = 9736 tumors), including head and neck squamous cell carcinoma (HNSCC) matched with corresponding normal samples from the cancer genome atlas (TCGA) and genotype-tissue expression (GTEx) (n = 8587 non-tumors) datasets, using the analysis of variance for the evaluation of differential expression. Here, CD47 is linked to head and neck squamous cell carcinoma.