S1PR1 and multiple sclerosis: Other S1P analogues exhibiting higher S1PR specificity than fingolimod (FTY720) include siponimod/BAF13 (a potent agonist of S1PR1 and S1PR5 but not of S1PR3), and RPC1063/ozanimod have entered phase III clinical trials for multiple sclerosis [38,123,124].