BIRC5 and breast carcinoma: Moreover, inhibition of SURVIVIN expression using siRNA in breast cancer cells (MCF-7 and MDA-MB-231) also promoted autophagy, whereas overexpression of SURVIVIN decreased LC3B puncta [60]; siHDAC2, siHDAC3, and siHDAC6 also decreased SURVIVIN expression and promoted LC3B-II conversion in these cells, whereas siHDAC1 led to opposite results [60].