EZH2 and colorectal cancer: Similarly, in colorectal cancer cells (Lovo, HCT115, and DLD-1), inhibition of EZH2, using the chemical UNC1999 or GSK343 inhibitors, increased autophagy [36], but UNC1999 was still able to promote autophagy in ATG5-/- cells, cells treated with 3-MA, or cells expressing a dominant negative mutant of ULK1, suggesting that EZH2i could induce non-canonical autophagy in this model.