SQSTM1 and triple-negative breast carcinoma: Similarly, blockade of panobinostat-induced autophagy using CQ in triple negative breast cancer cells lines (MDA-MB231 and SUM159PT) also led to the accumulation of ubiquitinylated proteins such as SQSTM1/P62-Ub and promoted both cell death in vitro and decrease of tumor growth in xenograph models [54].