Moreover, cotreatment of TNBC cells (MDA-MB-231 and MDA-MB-468) with LBH549, an HDACi, and Mevastatin, a HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase) inhibitor, increased apoptosis and reduced tumor growth in nude mice models as compared with effects obtained with the molecules used alone [104]. This evidence concerns the gene HMGCR and neoplasm.