Inhibition of EZH2, using siRNA or EZH2i DZNep, in colorectal cancer cells (RKO and HCT116), also increased LC3B-II levels and the expression of the ATG-related protein AMBRA1 (autophagy and BECLIN-1 regulator 1) and favored apoptosis but inhibited cell proliferation and migration [33]. Here, AMBRA1 is linked to colorectal cancer.