In NSCLC (A549 and H1299) cell lines, resveratrol, an activator of SIRT1, increased apoptosis and autophagy (increase of BECLIN-1 and LC3B-II, decrease of SQSTM1/P62, P-MTOR, and P-AKT) [117]. This evidence concerns the gene SQSTM1 and non-small cell lung carcinoma.