PTEN and cancer: Specifically, Seo and colleagues demonstrated that both RNA-based anti-miR-21 conjugated with a cationic Poly(Amine-Co-Ester) (PACE) and Peptide Nucleic Acid (PNA) anti-miR-21 conjugated with a copolymer of Poly(Lactic Acid) and Hyperbranched Polyglycerol (PLA-HPG), provided an efficient intracellular delivery system to inhibit miR-21 expression, leading to PTEN upregulation and apoptosis of human GBM (Glyoblastoma Multiforme) cancer cells.