Of note, miR-146a has been shown to directly target NOX4 (NADPH Oxidase 4) [63], causing an increased production of Extracellular Matrix (ECM) proteins in endothelial cells and in the retina of rats with glucose-induced diabetes [64], thus potentially representing a candidate target for the treatment of diabetic neuropathy. Here, NOX4 is linked to diabetic neuropathy.