RUNX1 and acute myeloid leukemia: The most represented (n = 3) compound in the top 10 DSigDB drugs associated with the Hoxadel signature, Anisomycin, was recently identified as an expression mimic of mutant RUNX-1 (mt-RUNX-1) knockdown with specific potency against cells from AML patients with germline or somatic mt-RUNX-1 [51].