BDNF and Wilms tumor, aniridia, genitourinary anomalies, intellectual disability, and obesity syndrome: Patients that were diagnosed with WAGRO have deletions that also encompass BDNF. BDNF is also involved in energy homeostasis in humans and haploinsufficiency is correlated with higher BMI (Body Mass Index), increased appetite, and childhood-onset obesity compared to WAGR patients without BDNF deletion [126,128].