Among the most prominently induced are Pafah1b1 (platelet activating factor acetyl hydrolase 1B)/Lis1 (lissencephaly type 1), Peripherin and Annexin A2, and siRNA knockdown of each of these proteins significantly reduced the numbers of PRV capsids undergoing retrograde traffic along the axon [48]. Here, PAFAH1B1 is linked to classic lissencephaly.