SOAT1 and cancer: Upstream of STAT proteins, JAK kinases are mutated in a broad range of diseases from severe combined immunodeficiency to various forms of cancer, including JAK1 in acute myeloid leukemia, JAK2 in myeloproliferative diseases and JAK3 in different leukemias and lymphomas, and inhibitors against JAK kinases are already approved by the US Food and Drug Administration (FDA) for clinical use [27].