KDR and neoplasm: It is thought that by inhibiting VEGF binding to VEGFR-2 and the receptor's subsequent autophosphorylation, apatinib suppresses endothelial cell proliferation, and angiogenesis.[28] It may also inhibit VEGFR-2-mediated down stream phosphorylation of extracellular signal-regulated kinase (ERK), resulting in antiangiogenic and anticancer effects.[28] VEGFR-2 level in the tumor tissue of our patient was overexpressed, which might be the main reason for the anticancer effect of apatinib.