UBE3A and hereditary disease: AS is a kind of neurological development-impacting genetic disease.[1] The prevalence of AS has been estimated to be approximately 1 in 15,000 individuals.[2] Furthermore, AS has been verified to be a maternally inherited disorder caused by the dysfunction of the ubiquitin-protein ligase E3A (UBE3A) gene that encodes ubiquitin-protein ligase E3A.