CUL4A is a scaffold protein of ubiquitin ligase E3 complex, and involves the ubiquitination and degradation of tumor suppressor genes, including p21,[10] p27,[11] and p53.[12] Thus, CUL4A has been regarded as an oncogene, but it remains unknown whether CUL4A plays a role in NPC. The gene discussed is CUL4A; the disease is nasopharyngeal carcinoma.