Scaled to 10% reduction in relative risk of CHD, CETP rs247617 and HMGCR rs12916 had near-identical associations with Friedewald-estimated LDL cholesterol (Fig 1) and similar associations for apolipoprotein B. In contrast, when LDL cholesterol was defined on the basis of cholesterol transported in LDL based on particle size (diameter 18–26 nm) and measured via nuclear magnetic resonance (NMR) spectroscopy, CETP expression lowering allele had no association with this size-specific LDL cholesterol (0.02 SDs; 95% CI: −0.10 to 0.05). This evidence concerns the gene HMGCR and coronary artery disorder.