H19 and neoplasm: Both lncRNA HOTAIR and MALAT1 are revealed to be highly expressed in many tumor tissues, but they were downregulated in patients who are resistant to gefitinib.17, 18 LncRNA H19 plays an oncogenic role in NSCLC, and promotes tumor cell proliferation and migration,19 while acts as a tumor suppressor in thyroid cancer.20 Therefore, the function of lncRNA is not static and may be related to the intracellular environment.