Corresponding to the increase in DANCR in these cells, in vitro viability (Fig. 5B,C), migration (Fig. 5D,E), and invasion (Fig. 5F,G) were significantly stimulated (P < 0.05, when compared with vector cells), as was the xenograft growth (Fig. 5H–K) and lung metastasis (Fig. S2C,D) in vivo (P < 0.05, when compared with vector cells), suggesting that DANCR was sufficient to induce malignant transformation of normal breast epithelial cells and boost the malignancy of breast cancer cell lines of low malignancy. Here, DANCR is linked to breast cancer.