TNF and bacterial infectious disease: ,21 It has been demonstrated that the mice model of bacterial infection with STMinduces an inflammatory process with changing in the levels of biochemical markersof inflammation, such as interleukin-1 (IL-1), interleukin-10 (IL-10),interleukin-12 (IL-12), tumor necrosis factor-α (TNF-α), and nitric oxide16,22 along the progress of infection.