Immunohistochemistry of renal biopsies from patients with LN confirmed that IFN-α promoted an antiangiogenic signature through repression of vascular endothelial growth factor (VEGF)-A and induction of an IL-1R antagonist, which correlated with decreased renal vascular density and vascular rarefaction, interfering with vascular repair in SLE [20]. The gene discussed is VEGFA; the disease is systemic lupus erythematosus.