Although current poly‐GA models suggest that poly‐GA is not sufficient to mimic the complete pathophysiology of ALS/FTD in mice (Zhang et al, 2016; Schludi et al, 2017), targeting poly‐GA may be sufficient to prevent ALS/FTD, which should be tested in C9orf72 BAC mice in the future (Jiang et al, 2016; Liu et al, 2016). This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.